Enantioselective Construction of Pyrimidine‐Fused Diazepinone Derivatives Bearing a Tertiary Stereogenic Center Enabled by Iridium‐Catalysed Intramolecular Allylic Substitution | Zendy

Jiang Xiaoding | Zendy; Pan Bendu | Zendy; Qian Xu | Zendy; Liang Hao | Zendy; Zhang Yaqi | Zendy; Chen Bin | Zendy; He Xiaobo | Zendy; Chan Hoi Shan | Zendy; Chan Albert S. C. | Zendy; Qiu Liqin | Zendy

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Enantioselective Construction of Pyrimidine‐Fused Diazepinone Derivatives Bearing a Tertiary Stereogenic Center Enabled by Iridium‐Catalysed Intramolecular Allylic Substitution

Author(s) -

Jiang Xiaoding,

Pan Bendu,

Qian Xu,

Liang Hao,

Zhang Yaqi,

Chen Bin,

He Xiaobo,

Chan Hoi Shan,

Chan Albert S. C.,

Qiu Liqin

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202100444

Subject(s) - stereocenter , enantioselective synthesis , allylic rearrangement , chemistry , intramolecular force , iridium , pyrimidine , stereochemistry , biphenyl , combinatorial chemistry , catalysis , organic chemistry

The iridium‐catalysed enantioselective intramolecular allylic substitution of pyrimidine‐tethered allylic carbonates was developed. A wide range of chiral pyrimidine‐fused diazepinone derivatives were successfully constructed in 88–96% yields with 85–99% ees. This work further highlights the power of chiral‐bridged biphenyl phosphoramidites in asymmetric synthesis.

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