Premium
Synthesis of C ‐ and N ‐Substituted 1,5,2,6‐Dithiadiazocanes –Electrophilic‐Nucleophilic Thioamination (ENTA) Reagents
Author(s) -
Javorskis Tomas,
Jurys Arminas,
Bagdžiūnas Gintautas,
Orentas Edvinas
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100424
Subject(s) - chemistry , electrophile , reagent , nucleophile , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
A synthetic method is presented for S−N bond formation starting from cheap and affordable materials. We show that (un)substituted N ‐protected cyclic eight‐membered C 2 ‐symmetric sulfenamides have been prepared in a few steps using this procedure. The synthetic utility of these ambipolar derivatives was demonstrated in a variety of synthetic transformations affording different S,N ‐heterocyles of pharmaceutical relevance in one or two steps from simple starting materials.