Premium
Cobalt‐Catalyzed C−H Alkoxylation of Ferrocenes with Alcohols under Mild Conditions
Author(s) -
Zhang ZhuoZhuo,
Cheng Jie,
Yao QiJun,
Yue Qiang,
Zhou Gang
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100423
Subject(s) - chemistry , cobalt , ferrocene , catalysis , alkoxide , reagent , amide , alcohol , solvent , acetonitrile , organic chemistry , medicinal chemistry , combinatorial chemistry , electrochemistry , electrode
Herein we reported a protocol for synthesis of oxy‐substituted ferrocenes via cobalt‐catalyzed direct C−H alkoxylation under mild conditions. Notably, alcohol serves as an both alkoxide reagent and a solvent. Various ferrocene amides including estrone‐derived ferrocene amide are compatible with these reaction conditions. Moreover, control experiments suggested that this alkoxylation might undergo a Co(III)/Co(IV)/Co(II) catalytic cycle.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom