One‐Pot Two‐Step Double Annulation of  N ‐Methoxybenzamides with Alkynes and Alkenes: Regioselective Construction of Isoindolo[2,1‐ b ]isoquinolin‐5(7 H )‐ones | Zendy

Naikawadi Praveen Kumar | Zendy; Mucherla Lingaswamy | Zendy; Dandela Rambabu | Zendy; Sambari Madhavi | Zendy; Kumar K. Shiva | Zendy

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One‐Pot Two‐Step Double Annulation of N ‐Methoxybenzamides with Alkynes and Alkenes: Regioselective Construction of Isoindolo[2,1‐ b ]isoquinolin‐5(7 H )‐ones

Author(s) -

Naikawadi Praveen Kumar,

Mucherla Lingaswamy,

Dandela Rambabu,

Sambari Madhavi,

Kumar K. Shiva

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202100414

Subject(s) - annulation , regioselectivity , chemistry , amide , alkyne , substrate (aquarium) , combinatorial chemistry , catalysis , stereochemistry , medicinal chemistry , organic chemistry , oceanography , geology

A one‐pot two‐step double annulation strategy to produce isoindolo[2,1‐ b ]isoquinolin‐5(7 H )‐ones via the reaction of N ‐methoxybenzamides with symmetrical/unsymmetrical alkynes and alkenes has been developed, which proceeds through Ru‐catalysed unsymmetrical double annulations using a single DG under single catalytic conditions. Furthermore, we have developed amide‐alkyne regioselective annulations using unsymmetrical internal alkynes having oxygen/nitrogen substituents leading to a single isomer. The developed procedure offers broad substrate scope, tolerates a wide range of functional groups and affords good product yields.

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