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A Photoinduced Multicomponent Regioselective Synthesis of 1,4,5‐Trisubstituted‐1,2,3‐Triazoles: Transition Metal‐, Azide‐ and Oxidant‐Free Protocol
Author(s) -
Sai Allaka Bhargava,
Basavoju Srinivas,
Rama Krishna Gamidi
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100321
Subject(s) - chemistry , regioselectivity , azide , isatin , transition metal , combinatorial chemistry , schiff base , organic chemistry , stereochemistry , catalysis
Abstract A transition metal‐ and azide‐free approach is explored to synthesize 1,4,5‐trisubstituted‐1,2,3‐triazoles under sunlight. The reaction proceeds via C−N and N−N bond formations. These regioselective 1,2,3‐triazoles are obtained from isatin Schiff bases, benzaldehydes and tosylhydrazine in the presence of base. This protocol offers the structurally diverse 1,2,3‐triazole derivatives with 75–90% yields.