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Enantioselective Catalyzed Synthesis of Amino Derivatives Using Electrophilic Open‐Chain N ‐Activated Ketimines
Author(s) -
Lupidi Gabriele,
Palmieri Alessandro,
Petrini Marino
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100292
Subject(s) - chemistry , electrophile , enantioselective synthesis , moiety , nucleophile , catalysis , reagent , sulfonyl , nitrogen atom , lewis acids and bases , organocatalysis , combinatorial chemistry , organic chemistry , medicinal chemistry , group (periodic table) , alkyl
N ‐Activated ketimines are characterized by the presence of acyl, sulfonyl, and phosphinoyl groups linked to the nitrogen atom of the azomethine system. These electron‐withdrawing groups enhance the electrophilic character of the imino moiety allowing the addition of even weak nucleophilic reagents. The presence of the oxygen atoms in these activating groups with its coordinating and Lewis or Brønsted properties is of paramount importance in asymmetric catalyzed reactions. This review collects the results that have appeared in the literature during the last two decades on the utilization of open‐chain N ‐activated ketimines for the synthesis of optically active α‐disubstituted and α‐trisubstituted amino derivatives including nitrogen‐containing heterocyclic compounds.