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η 6 ‐Arene CH−O Interaction Directed Dynamic Kinetic Resolution – Asymmetric Transfer Hydrogenation (DKR‐ATH) of α‐Keto/enol‐Lactams
Author(s) -
Luo Zhonghua,
Sun Guodong,
Wu Shuming,
Chen Yong,
Lin Yicao,
Zhang Lei,
Wang Zhongqing
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100288
Subject(s) - chemistry , kinetic resolution , enol , transfer hydrogenation , aryl , catalysis , asymmetric hydrogenation , combinatorial chemistry , stereochemistry , computational chemistry , enantioselective synthesis , organic chemistry , ruthenium , alkyl
A dynamic kinetic resolution – asymmetric transfer hydrogenation (DKR‐ATH) methodology of α‐keto/enol‐lactams was developed. We also propose a possible catalytic mechanism evolving a transition state stabilized by η 6 ‐arene CH−O interaction. The efficient approach can be applied to a wide range of substrates including non‐aryl ones which would be difficult to prepare by other asymmetric reduction methods.