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Rhodium‐Catalyzed C−H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N ‐Oxides
Author(s) -
Li Yuan,
Fang Feifei,
Zhou Jianhui,
Li Jiyuan,
Wang Run,
Liu Hong,
Zhou Yu
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100239
Subject(s) - isoquinoline , chemistry , annulation , rhodium , propargyl , catalysis , aryl , regioselectivity , organic chemistry , medicinal chemistry , cascade reaction , alkyl
A β ‐hydroxy elimination instead of common oxidization to carbonyl group in secondary propargyl alcohols was successfully developed to form 2‐benzyl substituted isoquinoline N ‐oxides by a Rhodium‐catalyzed C−H activation and annulation cascade, in which moderate to excellent yields (up to 92%) could be obtained under mild reaction conditions, along with good regioselectivity, broad generality and applicability.