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Ir(NHC)‐Catalyzed Synthesis of β‐Alkylated Alcohols via Borrowing Hydrogen Strategy: Influence of Bimetallic Structure
Author(s) -
Sung Kihyuk,
Lee Mihyun,
Cheong YeonJoo,
Kim Yu Kwon,
Yu Sungju,
Jang HyeYoung
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100219
Subject(s) - chemistry , bimetallic strip , catalysis , alkylation , iridium , carbene , reactivity (psychology) , intramolecular force , primary (astronomy) , organic chemistry , coupling reaction , combinatorial chemistry , medicine , physics , alternative medicine , pathology , astronomy
Multi N ‐heterocyclic carbene(NHC)‐modified iridium catalysts were employed in the β‐alkylation of alcohols; dimerization of primary alcohols (Guerbet reaction), cross‐coupling of secondary and primary alcohols, and intramolecular cyclization of alcohols. Mechanistic studies of Guerbet reaction, including kinetic experiments, mass analysis, and density functional theory (DFT) calculation, were employed to explain the fast reaction promoted by bimetallic catalysts, and the dramatic reactivity increase of monometallic catalysts at the late stage of the reaction.