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The Trityl‐Cation Mediated Phosphine Oxides Reduction
Author(s) -
Laye Claire,
Lusseau Jonathan,
Robert Frédéric,
Landais Yannick
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100189
Subject(s) - chemistry , phosphine , phosphonium , phosphine oxide , alkyl , silylation , silane , salt (chemistry) , reducing agent , phosphonium salt , organic chemistry , medicinal chemistry , catalysis
Reduction of phosphine oxides into the corresponding phosphines using PhSiH 3 as a reducing agent and Ph 3 C + [B(C 6 F 5 ) 4 ] − as an initiator is described. The process is highly efficient, reducing a broad range of secondary and tertiary alkyl and arylphosphines, bearing various functional groups in generally good yields. The reaction is believed to proceed through the generation of a silyl cation, which reaction with the phosphine oxide provides a phosphonium salt, further reduced by the silane to afford the desired phosphine along with siloxanes.