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Transition‐Metal‐Free Synthesis of Unsymmetrical Disulfides via Three‐Component Reaction of Thiosulfonates, Thiourea and Alkyl halides
Author(s) -
Wang Dungai,
He Quan,
Shi Keqiang,
Xiong Mingteng,
Zhou Yifeng,
Pan Yuanjiang
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100165
Subject(s) - chemistry , thiourea , alkyl , halide , transition metal , combinatorial chemistry , component (thermodynamics) , organic chemistry , polymer chemistry , catalysis , physics , thermodynamics
A transition‐metal‐free approach to synthesize unsymmetrical disulfides is reported that relies on a K 2 CO 3 ‐promoted one‐pot reaction of thiosulfonates, thiourea and alkyl halides under mild conditions. The protocol tolerates a wide range of substrates, leading to various types of unsymmetrical disulfides in moderate to excellent yields. More importantly, the late‐stage modification of natural products and drug molecules was also achieved.