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Assembly of 5‐Aminoimidazoles via Palladium‐Catalysed Double Isocyanide Insertion Reaction
Author(s) -
Wang Xu,
Fu JinPing,
Mo JiaHui,
Tian YuHong,
Liu ChunYou,
Tang HaiTao,
Sun ZiJun,
Pan YingMing
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100142
Subject(s) - chemistry , palladium , isocyanide , domino , cleavage (geology) , tandem , cascade reaction , bond cleavage , photochemistry , polymer chemistry , combinatorial chemistry , stereochemistry , catalysis , organic chemistry , materials science , geotechnical engineering , fracture (geology) , engineering , composite material
A palladium‐catalysed tandem cyclisation reaction of amidoximes, isocyanides and amines to produce 5‐aminoimidazoles was developed. Various 5‐aminoimidazoles were prepared in good to excellent yields under mild conditions. This elegant domino process involves the effective cleavage of the N−O bond and the formation of new C−C and C−N bonds in a single operation.