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Front Cover Picture: Zinc‐Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2‐Aryl‐Substituted Pyrrolidines as Pharmaceutical Building Blocks (5/2021)
Author(s) -
Węglarz Izabela,
Michalak Karol,
Mlynarski Jacek
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202100049
Subject(s) - hydrosilylation , chemistry , enantioselective synthesis , aryl , catalysis , combinatorial chemistry , zinc , silane , organic chemistry , alkyl
The front cover picture illustrates the application of Zn‐complex as a key catalyst for enantioselective hydrosilylation of cyclic imines. As the replacement of platinum‐group metals is currently an interesting challenge in catalysis, a promising alternative in asymmetric hydrosilylation, is to use environmentally benign and easily accessible chiral Zn‐based catalysts. I. Węglarz, K. Michalak and J. Mlynarski show that in situ generated zinc‐ProPhenol complex with silane affords pharmaceutically relevant enantioenriched 2‐aryl‐substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee ). Details can be found in the communication by Jacek Mlynarski and co‐workers (I. Węglarz, K. Michalak, J. Mlynarski, Adv. Synth. Catal . 2021 , 363 , 1317–1321; DOI: 10.1002/adsc.202001043).