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Recent Advances and Strategies for the Transition‐Metal‐Catalyzed C−H Functionalization of N ‐Nitrosoanilines
Author(s) -
Chaudhary Priyanka,
Kandasamy Jeyakumar,
Macabeo Allan Patrick G.,
Tamargo Ramuel John Inductivo,
Lee Yong Rok
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001613
Subject(s) - chemistry , surface modification , palladium , transition metal , rhodium , catalysis , iridium , ruthenium , combinatorial chemistry , functional group , nitroso , organic chemistry , polymer
Abstract The challenges faced in the activation and functionalization of C−H bonds while producing high‐value aromatic intermediates are significant for synthetic organic chemistry. This review summarizes the advancements made toward the C−H functionalization of N ‐nitrosoanilines in the past decade, in which the nitroso group coordinates to a transition metal, such as rhodium, palladium, cobalt, iridium, and ruthenium, acting as a directing group to allow the activation of the ortho C−H bond. The versatility of this synthetic approach has led to the regio‐ and chemoselective introduction of various functional groups giving rise to aromatic congeners with diverse functional and structural properties. C−H functionalized nitroso compounds can be further transformed into valuable synthetic intermediates and unique heterocyclic compounds. A description of the mechanism underlying each reaction is also included. This review includes the following sections: