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A 1,4‐Palladium Migration/Heck Sequence with Unactivated Alkenes: Stereoselective Synthesis of Trisubstituted 1,3‐Dienes
Author(s) -
Xue ZeJian,
Li MengYao,
Zhu BinBin,
He ZhiTao,
Feng ChenGuo,
Lin GuoQiang
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001589
Subject(s) - chemistry , palladium , stereoselectivity , heck reaction , cascade , sequence (biology) , organic chemistry , catalysis , combinatorial chemistry , biochemistry , chromatography
The palladium‐catalyzed cross‐coupling of ortho ‐vinyl aromatic bromides and olefins was achieved through a controllable 1,4‐palladium migration/Heck cascade protocol. The reaction represents a mild, efficient and highly stereoselective method for the synthesis of trisubstituted 1,3‐dienes, especially for triaryl‐substituted ones.