Exploring the Reactivity of Propargylic Ester: Acyloxy and Acyl Migratory Rearrangement Relay Enabled by Formal Double Isocyanide Insertion | Zendy

Fei Youwen | Zendy; Hu Jie | Zendy; Wang Zhishuang | Zendy; Cui Lei | Zendy; Jia Xueshun | Zendy; Li Chunju | Zendy; Li Jian | Zendy

Premium

Exploring the Reactivity of Propargylic Ester: Acyloxy and Acyl Migratory Rearrangement Relay Enabled by Formal Double Isocyanide Insertion

Author(s) -

Fei Youwen,

Hu Jie,

Wang Zhishuang,

Cui Lei,

Jia Xueshun,

Li Chunju,

Li Jian

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202001577

Subject(s) - chemistry , isocyanide , intermolecular force , reactivity (psychology) , migratory insertion , stereochemistry , double bond , medicinal chemistry , molecule , polymer chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology

A rearrangement of propargylic pivalate with isocyanide under transition metal‐free conditions is disclosed. Intermolecular 1,3‐acyloxy and acyl migration enables the rapid formation of a C( sp 2 )−C( sp 3 ) bond from a C−O bond and the synthesis of polysubstituted 5‐iminopyrrolones.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research