Synthesis of Diversely Substituted Imidazolidines  via  [3+2] Cycloaddition of 1,3,5‐Triazinanes with Donor‐Acceptor Aziridines and Their Anti‐Tumor Activity | Zendy

Shi Zhichao | Zendy; Fan Tingting | Zendy; Zhang Xun | Zendy; Zhan Feng | Zendy; Wang Zhe | Zendy; Zhao Lei | Zendy; Lin JinShun | Zendy; Jiang Yuyang | Zendy

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Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5‐Triazinanes with Donor‐Acceptor Aziridines and Their Anti‐Tumor Activity

Author(s) -

Shi Zhichao,

Fan Tingting,

Zhang Xun,

Zhan Feng,

Wang Zhe,

Zhao Lei,

Lin JinShun,

Jiang Yuyang

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202001569

Subject(s) - chemistry , cycloaddition , acceptor , stereochemistry , combinatorial chemistry , structural isomer , catalysis , organic chemistry , physics , condensed matter physics

A Y(OTf) 3 ‐catalyzed [3+2] cycloaddition of 1,3,5‐triazinanes with donor‐acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation of imidazolidines through an S N 1‐like pathway. Furthermore, these imidazolidines exhibit promising anti‐tumor activity against a series of human cancer cell lines.

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