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Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5‐Triazinanes with Donor‐Acceptor Aziridines and Their Anti‐Tumor Activity
Author(s) -
Shi Zhichao,
Fan Tingting,
Zhang Xun,
Zhan Feng,
Wang Zhe,
Zhao Lei,
Lin JinShun,
Jiang Yuyang
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001569
Subject(s) - chemistry , cycloaddition , acceptor , stereochemistry , combinatorial chemistry , structural isomer , catalysis , organic chemistry , physics , condensed matter physics
A Y(OTf) 3 ‐catalyzed [3+2] cycloaddition of 1,3,5‐triazinanes with donor‐acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation of imidazolidines through an S N 1‐like pathway. Furthermore, these imidazolidines exhibit promising anti‐tumor activity against a series of human cancer cell lines.