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Synthesis of Unsymmetrical Azoxyarenes via Copper‐Catalyzed Aerobic Oxidative Dehydrogenative Coupling of Anilines with Nitrosoarenes
Author(s) -
Shi Chongyang,
Xu Boxia,
Fang Xiaolan,
Yu Xiaochun,
Jin Huile,
Wang Shun
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001526
Subject(s) - chemistry , catalysis , azoxy , copper , oxidative coupling of methane , substrate (aquarium) , oxidative phosphorylation , combinatorial chemistry , coupling (piping) , organic chemistry , metallurgy , biochemistry , oceanography , materials science , geology
A copper‐catalyzed oxidative dehydrogenative coupling of nitrosobenzenes with anilines for the synthesis of unsymmetrical azoxybenzenes was developed. This approach uses O 2 as the oxidant. The reaction products are diverse unsymmetrical azoxybenzenes rather than azobenzenes, which are obtained in the Mills reaction. The use of an inexpensive copper catalyst, a broad substrate scope, and mild reaction conditions make this protocol an atom‐economic and step‐economic procedure for preparing unsymmetrical azoxy compounds.