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PPTS‐Catalyzed Bicyclization Reaction of 2‐Isocyanobenzaldehydes with Various Amines: Synthesis of Diverse Fused Quinazolines
Author(s) -
Meng XiangHe,
Wu DanNi,
Zhang YuJia,
Zhao YuLong
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001512
Subject(s) - chemistry , pyridinium , catalysis , combinatorial chemistry , reaction conditions , quinazoline , organic chemistry
Abstract A PPTS (pyridinium p ‐toluenesulfonate)‐catalyzed bicyclization reaction of 2‐isocyanobenzaldehydes as 1,5‐dielectrophiles with various amines has been developed. The reaction not only provides a simple and efficient strategy for the assembly of structurally diverse fused quinazoline derivatives from readily available substrates under metal‐free and mild conditions in a single step with only water and hydrogen as the by‐products, but also opens the way to the application of o ‐formyl arylisocyanides in the synthesis of nitrogen‐containing heterocycles.