Palladium‐Catalyzed Carbonylative Synthesis of 2‐(Trifluoromethyl)quinazolin‐4(3 H )‐ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds | Zendy

Wang LeCheng | Zendy; Zhang Yu | Zendy; Chen Zhengkai | Zendy; Wu XiaoFeng | Zendy

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Palladium‐Catalyzed Carbonylative Synthesis of 2‐(Trifluoromethyl)quinazolin‐4(3 H )‐ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds

Author(s) -

Wang LeCheng,

Zhang Yu,

Chen Zhengkai,

Wu XiaoFeng

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202001502

Subject(s) - chemistry , palladium , nitro , trifluoromethyl , catalysis , reagent , combinatorial chemistry , nitro compound , medicinal chemistry , organic chemistry , alkyl

A procedure on palladium‐catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2‐(trifluoromethyl)quinazolin‐4(3 H )‐ones has been achieved. In this transformation, Mo(CO) 6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale.

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