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Visible‐Light‐Induced Three‐Component Intermolecular Trifluoromethyl‐Alkenylation Reactions of Unactivated Alkenes
Author(s) -
Guo YuanQiang,
Wang Kaihua,
Wang Ruiguo,
Song Hongjian,
Liu Yuxiu,
Wang Qingmin
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001434
Subject(s) - trifluoromethyl , chemistry , intermolecular force , substrate (aquarium) , functional group , styrene , surface modification , reagent , combinatorial chemistry , organic chemistry , photochemistry , molecule , alkyl , oceanography , copolymer , geology , polymer
Herein, we describe a practical protocol for efficient, mild, visible‐light‐induced three‐component intermolecular trifluoromethyl‐alkenylation reactions of unactivated alkenes. The protocol has good functional group tolerance and a broad substrate scope. Using this protocol, we not only introduced a trifluoromethyl group into alkenes but also converted unactivated alkenes to styrene‐based activated alkenes, in addition to accomplishing late‐stage functionalization of pharmaceutical intermediates.