Premium
Access to 10‐Phenanthrenols via Electrochemical C−H/C−H Arylation
Author(s) -
Mei Ruhuai,
Yang Chenrui,
Xiong Feng,
Mao Meihua,
Li Hongmei,
Sun Junmei,
Zou Liang,
Ma Wenbo,
Ackermann Lutz
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001431
Subject(s) - chemistry , oxidizing agent , intramolecular force , biphenyl , electrochemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , electrode
A protocol for the synthesis of 10‐phenanthrenol from 1‐biphenyl‐2‐ylethanone bearing an electron‐withdrawing group through metal‐ and oxidant‐free C−H/C−H arylation has been established. The electrochemical intramolecular cycloaromatization avoids the use of excess amounts of chemical oxidizing agents, and provides concise and regio‐selective access to a variety of valuable 10‐phenanthrenol derivatives.