[Bis(trifluoroacetoxy)iodo]benzene Mediated C‐3 Selenylation of Pyrido[1,2‐ a ]Pyrimidin‐4‐Ones Under Ambient Conditions | Zendy

Ghosh Prasanjit | Zendy; Chhetri Gautam | Zendy; Perl Eliyahu | Zendy; Das Sajal | Zendy

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[Bis(trifluoroacetoxy)iodo]benzene Mediated C‐3 Selenylation of Pyrido[1,2‐ a ]Pyrimidin‐4‐Ones Under Ambient Conditions

Author(s) -

Ghosh Prasanjit,

Chhetri Gautam,

Perl Eliyahu,

Das Sajal

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202001426

Subject(s) - chemistry , benzene , combinatorial chemistry , broad spectrum , benzene derivatives , medicinal chemistry , scalability , computational chemistry , organic chemistry , chemical synthesis , database , computer science , biochemistry , in vitro

Herein, we report the [Bis(trifluoroacetoxy)iodo]benzene mediated C−H bond arylselenylation of 4 H ‐Pyrido‐[1,2‐ a ]‐Pyrimidin‐4‐ones using readily available organodiselenides. This methodology is scalable and permits for the generation of a broad spectrum of functionally and structurally diverse selenoether derivatives in very promising yields (up to 98%). Notably, this protocol proceeds at ambient conditions and in the absence of a metal. The application of this methodology for the facile synthesis of ArSe substituted 5 H ‐thiazolo‐pyrido[3,2‐ a ]pyrimidin‐4‐ones is also demonstrated.

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