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Efficient and Clean Nickel Catalyzed α‐Allylation Reaction of Nitriles
Author(s) -
Mouhsine Bouchaib,
Karim Abdallah,
Dumont Clément,
Suisse Isabelle,
Sauthier Mathieu
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001338
Subject(s) - allylic rearrangement , catalysis , chemistry , nickel , acetonitrile , methanol , ligand (biochemistry) , alkyl , solvent , organic chemistry , medicinal chemistry , combinatorial chemistry , biochemistry , receptor
A clean method has been developed for the α‐allylation of phenyl and alpha alkyl phenyl acetonitrile with allylic alcohols. The reaction is catalyzed by nickel complexes in situ generated from a combination of Ni(cod) 2 and the dppf ligand and performed at 80 °C in methanol as reaction solvent. Accordingly to this simple and base‐free protocol that only yields water as a side‐product, many allylic nitriles were synthetized with good yields.