Selective Synthesis of Fused Tricyclic [1,3]oxazino[3,4‐ a ]indolone and Dihydropyrimido [1,6‐a]indolone  via  Rh(III)‐catalyzed [3+3] or [4+2] C−H Annulation | Zendy

Chen Junyu | Zendy; Zhong Tianshuo | Zendy; Zheng Xiangyun | Zendy; Yin Chuanliu | Zendy; Zhang Lei | Zendy; Zhou Jian | Zendy; Jiang Xinpeng | Zendy; Yu Chuanming | Zendy

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Selective Synthesis of Fused Tricyclic [1,3]oxazino[3,4‐ a ]indolone and Dihydropyrimido [1,6‐a]indolone via Rh(III)‐catalyzed [3+3] or [4+2] C−H Annulation

Author(s) -

Chen Junyu,

Zhong Tianshuo,

Zheng Xiangyun,

Yin Chuanliu,

Zhang Lei,

Zhou Jian,

Jiang Xinpeng,

Yu Chuanming

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202001286

Subject(s) - annulation , chemistry , tricyclic , catalysis , indole test , substrate (aquarium) , stereochemistry , scope (computer science) , combinatorial chemistry , medicinal chemistry , organic chemistry , oceanography , computer science , programming language , geology

A formation of fused tricyclic [1,3]oxazino[3,4‐ a ]indol‐1‐ones and dihydropyrimido[1,6‐ a ]indol‐1(2 H )‐ones via Rh(III)‐catalyzed [3+3] or [4+2] annulation of N ‐methoxy‐1 H ‐indole‐1‐carboxamides with sulfoxonium ylides has been developed. These selective annulation reactions were carried out by switching the additives and notable features of this protocol were low catalyst loading and a broad substrate scope providing the corresponding products in up to 99% yields.

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