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Visible‐Light Photoredox‐Catalyzed Tandem Trifluoro‐methylation/Cyclization/Remote Oxidation of 1,6‐Dienes: Access to CF 3 ‐Containing Five‐Membered Heterocycles
Author(s) -
Chun Jianlin,
Zhang Honglin,
Meng Fei,
Guo Kang,
Cao Shujun,
Fang Qin,
Li Jie,
Zhu Yingguang
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001272
Subject(s) - chemistry , trifluoromethylation , tandem , trifluoromethyl , photoredox catalysis , sulfoxide , catalysis , visible spectrum , dimethyl sulfoxide , combinatorial chemistry , photochemistry , photocatalysis , medicinal chemistry , organic chemistry , alkyl , materials science , physics , optoelectronics , composite material
A visible‐light photoredox‐catalyzed tandem trifluoromethylation/cyclization/remote oxidation of 1,6‐dienes has been achieved. A broad range of trifluoromethyl group‐containing tetrahydrofurans or tetrahydropyrroles could be generated in good yields and with excellent diastereoselectivity by using dimethyl sulfoxide (DMSO) as the oxidant. The mild and facile protocol affords direct access to trifluoromethyl group‐bearing tetrahydrofurans and tetrahydropyrroles via difunctionalization of olefins.