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Boron‐Catalyzed Dehydrative Friedel‐Crafts Alkylation of Arenes Using β ‐Hydroxyl Ketone as MVK Precursor
Author(s) -
San Htet Htet,
Huang Jie,
Lei Aye Seinn,
Tang XiangYing
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001269
Subject(s) - chemistry , friedel–crafts reaction , ketone , aniline , catalysis , alkylation , boron , pyrrole , organic chemistry , indole test , reagent , substrate (aquarium) , oceanography , geology
Boron‐catalyzed environmentally benign dehydrative Friedel‐Crafts alkylation of indole/pyrrole and aniline derivatives with β‐hydroxyl ketones has been developed for the first time. This method provides an efficient and green replacement of toxic and unstable methyl vinyl ketone (MVK) by safer and cheaper β‐hydroxyl ketone. The reaction features easy operation, wide substrate scope and significantly, only water is formed as by‐product.