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Visible‐Light‐Induced Controlled Oxidation of N ‐Substituted 1,2,3,4‐Tetrahydroisoquinolines for the Synthesis of 3,4‐Dihydroisoquinolin‐1(2 H )‐ones and Isoquinolin‐1(2 H )‐ones
Author(s) -
Bansode Ajay H.,
Suryavanshi Gurunath
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001266
Subject(s) - chemistry , substrate (aquarium) , scope (computer science) , isoquinoline , combinatorial chemistry , feature (linguistics) , rose bengal , visible spectrum , photochemistry , medicinal chemistry , organic chemistry , optoelectronics , computer science , linguistics , oceanography , philosophy , physics , programming language , geology
A visible light‐rose bengal‐TBHP mediated, controlled oxidation of N ‐substituted 1,2,3,4‐tetrahydroisoquinolines is developed for the synthesis of 3,4‐dihydroisoquinolin‐1(2 H )‐ones and isoquinolin‐1(2 H )‐ones. The present method feature's a broad substrate scope, good functional group tolerances, and the products were prepared in good to excellent yields. The developed methodology further demonstrated in the synthesis of isoindolo[2,1‐b] isoquinolin‐5(7 H )‐one (topoisomerase‐I inhibitor).