Premium
Multicomponent and One‐pot Syntheses of Quinoxalines
Author(s) -
Biesen Lukas,
Müller Thomas J. J.
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001219
Subject(s) - quinoxaline , chemistry , domino , combinatorial chemistry , organic chemistry , nanotechnology , catalysis , materials science
Quinoxalines represent bicyclic nitrogen‐containing heterocycles with a wide array of applications. They exhibit a multitude of biological activities relevant in medicinal chemistry as well as a plethora of luminescence properties. Quinoxaline syntheses exploit the whole raft of multicomponent syntheses from domino to sequential or consecutive reactions, harvesting well‐known synthetic concepts and reactions, such as Ugi‐reactions, but also leading to the development of novel reactions and sequences. Diversity‐oriented synthesis and transition metal catalyzed multicomponent reactions open efficient pathways to quinoxalines and quinoxaline‐containing moieties in a one‐pot fashion. This review outlines the underlying reaction‐based principles of multicomponent syntheses of quinoxalines and summarizes recent developments quinoxaline‐directed MCRs, illustrating their scopes.