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Highly Regio‐ and Enantioselective Organocatalytic γ‐Allylic Alkylation of Quinolines
Author(s) -
Meazza Marta,
Rios Ramon
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001213
Subject(s) - enantioselective synthesis , chemistry , regioselectivity , tsuji–trost reaction , quinoline , alkylation , organocatalysis , allylic rearrangement , ring (chemistry) , organic chemistry , stereochemistry , combinatorial chemistry , catalysis
We report the first synthesis of 2‐alkenylquinolines from 2‐allylquinolines and α,β‐unsaturated aldehydes. The reaction proceeds in a highly regioselective and enantioselective way and shows a broad tolerance of functionalities both in the aromatic ring of the enal and on the quinoline.