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Synthesis of Seleno Oxindoles via Electrochemical Cyclization of N ‐arylacrylamides with Diorganyl Diselenides
Author(s) -
Wang XinYu,
Zhong YuanFang,
Mo ZuYu,
Wu ShiHong,
Xu YanLi,
Tang HaiTao,
Pan YingMing
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001192
Subject(s) - chemistry , tandem , oxindole , electrochemistry , combinatorial chemistry , organic chemistry , catalysis , electrode , materials science , composite material
The tandem cyclization of acrylamide with diselenides facilitated by electrochemical oxidation was successfully developed. This strategy provided an environmentally friendly method for the construction of C−Se bond. A series of seleno oxindoles with pharmacological activity were obtained by using this well‐designed tandem cyclization strategy. The in vitro antitumor activity of the compounds was also screened through MTT assay. Results showed that the seleno oxindoles exhibited better antitumor activity than other oxindole derivatives.