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Transition Metal‐Free Synthesis of Substituted Isothiazoles via Three‐Component Annulation of Alkynones, Xanthate and NH 4 I
Author(s) -
Li Jian,
Li Jiaming,
Ji Xiaoliang,
Liu Qiang,
Chen Lu,
Huang Yubing,
Li Yibiao
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001179
Subject(s) - chemistry , xanthate , annulation , intramolecular force , transition metal , regioselectivity , hydroamination , combinatorial chemistry , tandem , organic chemistry , catalysis , materials science , composite material
A protocol was described to access diverse isothiazoles with functionalization potential via transition metal‐free three‐component annulation of alkynones, potassium ethylxanthate (EtOCS 2 K) and ammonium iodide (NH 4 I). A sequential regioselective hydroamination/thiocarbonylation/intramolecular cyclization cascade achieved the efficient formation of consecutive C−N, C−S and N−S bonds in a one‐pot process.