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P(III)‐Mediated Cascade C‐N/C‐S Bond Formation: A Protocol towards the Synthesis of N , S ‐Heterocycles and Spiro Compounds
Author(s) -
Polina Saibabu,
Putta V. P. Rama Kishore,
Gujjarappa Raghuram,
Singh Virender,
Pujar Prasad Pralhad,
Malakar Chandi C.
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001149
Subject(s) - chemistry , nucleophile , molecule , cascade , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , chromatography
A P(III)‐mediated entry towards construction of C−N/C−S bond has been devised. The developed heterocyclization method was exercised for the synthesis of a diverse range of N , S ‐heterocycles and related spiro molecules. P(NMe 2 ) 3 revealed the maximum efficacies under the aerobic reaction conditions and a spectrum of bis‐nucleophiles, and isothiocyanates were tolerated well to serve the access of manifold immense molecules.