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Palladium‐Catalyzed Regioselective and Diastereoselective C ‐Glycosylation by Allyl‐Allyl Coupling
Author(s) -
Li Junhao,
Zheng Nan,
Duan Xuelun,
Li Rui,
Song Wangze
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001136
Subject(s) - chemistry , regioselectivity , glycosylation , palladium , glycosyl , catalysis , glycosyl donor , combinatorial chemistry , glycoside , organic chemistry , biochemistry
A Pd‐catalyzed C ‐glycosylation reaction was developed by allyl‐allyl coupling process using Achmatowicz rearrangement products as donors and methylcoumarins as acceptors under mild conditions. This method featured regio‐ and diastereoselectivities, stereodivergent synthesis of C ‐glycosides. The glycosyl donors with controlled stereodiversity and glycosyl acceptors with fluorescent performace further highlighted this methodology.