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Electrochemical Oxidative Functionalization of Arylalkynes: Access to α,α‐Dibromo Aryl Ketones
Author(s) -
Wang Dan,
Wan Zhaohua,
Zhang Heng,
Lei Aiwen
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001105
Subject(s) - chemistry , surface modification , electrochemistry , aryl , combinatorial chemistry , oxidative phosphorylation , substrate (aquarium) , organic chemistry , electrode , biochemistry , alkyl , oceanography , geology
A general and effective protocol to synthesize α,α‐dibromo aryl ketones has been developed via an electrochemical oxidative method. The reaction proceeds smoothly at room temperature in an undivided cell without the addition of external oxidants. In the reaction process, LiBr acts as both bromine source and supporting electrolyte. This electrooxidation strategy has good substrate applicability and functional group compatibility. Moreover, the reaction could be scaled up efficiently in a continuous flow cell. The target product could undergo further functionalization for the synthesis of some useful heterocyclic compounds.

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