Palladium‐Catalyzed Selective Carbofunctionalization of Inert γ‐C( sp  3 )−O Bonds with 4‐Hydroxypyridin‐2( 1H )‐ones and 4‐Hydroxy‐ 2H ‐pyran‐2‐ones | Zendy

Guan Qifan | Zendy; Lin Cong | Zendy; Chen Sai | Zendy; Gao Fei | Zendy; Shen Liang | Zendy

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Palladium‐Catalyzed Selective Carbofunctionalization of Inert γ‐C( sp 3 )−O Bonds with 4‐Hydroxypyridin‐2( 1H )‐ones and 4‐Hydroxy‐ 2H ‐pyran‐2‐ones

Author(s) -

Guan Qifan,

Lin Cong,

Chen Sai,

Gao Fei,

Shen Liang

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202001091

Subject(s) - chemistry , palladium , pyran , catalysis , inert , amide , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry

The palladium‐catalyzed selective carbofunctionalization of inert γ‐C( sp 3 )−O bonds of aliphatic amides by using the strategy of sp 3 C−H activation/β‐O elimination/hydrocarbofunctionalization with the assistance of 8‐aminoquinolyl directing group is presented here. This method features a broad scope of both 4‐hydroxypyridin‐2( 1H )‐ones and 4‐hydroxy‐ 2H ‐pyran‐2‐ones, providing a versatile method for the synthesis of corresponding γ‐substituted amide derivatives.

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