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Palladium‐Catalyzed Selective Carbofunctionalization of Inert γ‐C( sp 3 )−O Bonds with 4‐Hydroxypyridin‐2( 1H )‐ones and 4‐Hydroxy‐ 2H ‐pyran‐2‐ones
Author(s) -
Guan Qifan,
Lin Cong,
Chen Sai,
Gao Fei,
Shen Liang
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001091
Subject(s) - chemistry , palladium , pyran , catalysis , inert , amide , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry
The palladium‐catalyzed selective carbofunctionalization of inert γ‐C( sp 3 )−O bonds of aliphatic amides by using the strategy of sp 3 C−H activation/β‐O elimination/hydrocarbofunctionalization with the assistance of 8‐aminoquinolyl directing group is presented here. This method features a broad scope of both 4‐hydroxypyridin‐2( 1H )‐ones and 4‐hydroxy‐ 2H ‐pyran‐2‐ones, providing a versatile method for the synthesis of corresponding γ‐substituted amide derivatives.