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Front Cover Picture: Iridium‐Catalyzed Enantioselective Transfer Hydrogenation of Ketones Controlled by Alcohol Hydrogen‐Bonding and sp 3 ‐C−H Noncovalent Interactions (Adv. Synth. Catal. 21/2020)
Author(s) -
Murayama Hiroaki,
Heike Yoshito,
Higashida Kosuke,
Shimizu Yohei,
Yodsin Nuttapon,
Wonggwa Yutthana,
Jungsuttiwong Siriporn,
Mori Seiji,
Sawamura Masaya
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001037
Subject(s) - transfer hydrogenation , iridium , chemistry , enantioselective synthesis , front cover , catalysis , asymmetric hydrogenation , non covalent interactions , noyori asymmetric hydrogenation , phosphine , hydrogen bond , medicinal chemistry , stereochemistry , organic chemistry , ruthenium , cover (algebra) , molecule , mechanical engineering , engineering
The front cover picture , designed by three groups from Hokkaido (Japan: ramanus rose), Ibaraki (Japan: plum), and Ubon Ratchathani (Thailand: lotus) illustrates the enantioselective transfer hydrogenation reactions of ketones with formic acid under iridium catalysis. Rationally designed prolinol‐phosphine chiral ligands are highly effective for the hydrogenation of ketones including tert ‐alkylaryl ketones in up to 99% yield and with up to 99.8% ee . DFT calculations showed non‐covalent interactions including O–H⋅⋅⋅O/ sp 3 ‐C–H⋅⋅⋅O two‐point hydrogen‐bonding and C–H/π interactions. Details of this work can be found in the communication on pages 4655–4661 (H. Murayama, Y. Heike, K. Higashida, Y. Shimizu, N. Yodsin, Y. Wongnongwa, S. Jungsuttiwong, S. Mori, M. Sawamura, Adv. Synth. Catal . 2020 , 362 , 4655–4661; DOI: 10.1002/adsc.202000615).