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Iron‐Catalyzed and Air‐Mediated C( sp 3 )−H Phosphorylation of 1,3‐Dicarbonyl Compounds Involving C−C Bond Cleavage
Author(s) -
Ou Yingcong,
Huang Yuanting,
Liu Yu,
Huo Yanping,
Gao Yang,
Li Xianwei,
Chen Qian
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001020
Subject(s) - chemistry , catalysis , yield (engineering) , bond cleavage , cleavage (geology) , phosphorylation , functional group , medicinal chemistry , stereochemistry , coupling reaction , organic chemistry , biochemistry , materials science , polymer , geotechnical engineering , fracture (geology) , engineering , metallurgy
A C( sp 3 )−H phosphorylation has been achieved via the iron‐catalyzed cross‐coupling reactions between 1,3‐dicarbonyl compounds and P(O)−H compounds involving C−C bond cleavages with air as the oxidant. This transformation provides a straightforward way to construct C( sp 3 )−P bonds, leading to the formation of β‐ketophosphine oxides in up to 93% yield with good functional group tolerance.