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β ‐Trifluoromethyl α , β ‐unsaturated Ketones: Efficient Building Blocks for Diverse Trifluoromethylated Molecules
Author(s) -
Chaudhary Bharatkumar,
Kulkarni Neeraj,
Saiyed Nehanaz,
Chaurasia Meenakshi,
Desai Surbhi,
Potkule Sagar,
Sharma Satyasheel
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001018
Subject(s) - trifluoromethyl , stereocenter , chemistry , molecule , structural motif , organic molecules , combinatorial chemistry , organic chemistry , stereochemistry , enantioselective synthesis , catalysis , alkyl , biochemistry
Abstract The trifluoromethyl (CF 3 ) group is an advantageous structural motif in various biologically active molecules as well as materials, which is depicted by steadily increasing demand from the industries involved in drug discovery, agrochemicals and material development. β ‐trifluoromethyl α , β ‐unsaturated carbonyl compounds constitute a very efficient building blocks as starting material in the synthesis of fluorinated molecules. Their usage for the synthesis of various heterocycles and organic molecules bearing stereogenic carbon containing CF 3 motif has received significant attention during the recent times. This review provides the existing methods for the synthesis of β ‐substituted trifluoromethyl‐ α , β ‐unsaturated ketones and the efforts made by researchers for the synthetic development through various reactions by employing them as synthetic building blocks for trifluoromethylated organic scaffolds.