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Asymmetric Oxidative Mannich Reactions
Author(s) -
RostollBerenguer Jaume,
Blay Gonzalo,
Pedro José R.,
Vila Carlos
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202001017
Subject(s) - electrophile , chemistry , enantioselective synthesis , mannich reaction , scope (computer science) , organocatalysis , combinatorial chemistry , catalysis , oxidative phosphorylation , organic chemistry , computer science , biochemistry , programming language
The asymmetric Mannich reaction is one of the most straightforward methodologies for the enantioselective synthesis of chiral amines. In general, asymmetric Mannich reactions involve the use of imines as electrophiles. However, in recent years, several asymmetric oxidative Mannich reactions have been reported using amines as electrophiles. This review provides an overview of these recent publications, including the different oxidants used and the scope and limitations of the different catalytic systems.