Free‐radical Initialized Cyclization of 2‐(3‐Arylpropioloyl)benzaldehydes with Toluene Derivatives: Access to Benzylated 1,4‐Naphthoquinones via Copper‐Catalyzed Cascade Reaction | Zendy

Zhu Bingbin | Zendy; Han Hang | Zendy; Su WeiKe | Zendy; Yu Chuanming | Zendy; Jiang Xinpeng | Zendy

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Free‐radical Initialized Cyclization of 2‐(3‐Arylpropioloyl)benzaldehydes with Toluene Derivatives: Access to Benzylated 1,4‐Naphthoquinones via Copper‐Catalyzed Cascade Reaction

Author(s) -

Zhu Bingbin,

Han Hang,

Su WeiKe,

Yu Chuanming,

Jiang Xinpeng

Publication year - 2021

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000975

Subject(s) - chemistry , cascade , toluene , catalysis , radical cyclization , copper , substrate (aquarium) , cascade reaction , combinatorial chemistry , functional group , organic chemistry , oceanography , polymer , chromatography , geology

A copper‐catalyzed cyclization reaction of 2‐(3‐arylpropioloyl)benzaldehydes was developed, leading to benzylated 1,4‐naphthoquinones via radical‐triggered cascade cyclization. This example of an acylbenzylation involving internal alkynes could be carried out with a broad substrate scope and wide functional group tolerance.

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