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Free‐radical Initialized Cyclization of 2‐(3‐Arylpropioloyl)benzaldehydes with Toluene Derivatives: Access to Benzylated 1,4‐Naphthoquinones via Copper‐Catalyzed Cascade Reaction
Author(s) -
Zhu Bingbin,
Han Hang,
Su WeiKe,
Yu Chuanming,
Jiang Xinpeng
Publication year - 2021
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000975
Subject(s) - chemistry , cascade , toluene , catalysis , radical cyclization , copper , substrate (aquarium) , cascade reaction , combinatorial chemistry , functional group , organic chemistry , oceanography , polymer , chromatography , geology
A copper‐catalyzed cyclization reaction of 2‐(3‐arylpropioloyl)benzaldehydes was developed, leading to benzylated 1,4‐naphthoquinones via radical‐triggered cascade cyclization. This example of an acylbenzylation involving internal alkynes could be carried out with a broad substrate scope and wide functional group tolerance.