Premium
Ruthenium(II)‐Catalyzed Synthesis of Indolo[2,1‐a]isoquinolines through Double Oxidative Annulation Reaction of Phenyl Isocyanates with Di(hetero)aryl Alkynes
Author(s) -
Kumar Amrendra,
Kant Ruchir,
Tadigoppula Narender
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000963
Subject(s) - chemistry , aryl , annulation , isocyanate , ruthenium , indole test , catalysis , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl , polyurethane
Indole‐containing polycyclic hetero aromatic compounds are synthesized by multistep process, which have wide application in biological activities and organic semi‐conductor materials. Herein we report the one‐pot method for the synthesis of polysubstituted indolo[2,1‐a]isoquinolines by Ru(II) catalyzed double aryl/hetero aryl C( sp 2 )−H activation through in‐situ installed carbamide of phenyl isocyanate and di(hetero)aryl substituted alkynes in the presence of Cu(OAc) 2 .H 2 O as an oxidant and CsOAc as an additive at 120 °C for 3 h in good to excellent yields.