Palladium‐Catalyzed Distal C−H Selenylation of 2‐Aryl Acetamides with Diselenides and Selenyl Chlorides | Zendy

He Meicui | Zendy; Gu Linghui | Zendy; Tan Yuqiang | Zendy; Wang Yang | Zendy; Wang Yuchi | Zendy; Zhang Chunran | Zendy; Ma Wenbo | Zendy

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Palladium‐Catalyzed Distal C−H Selenylation of 2‐Aryl Acetamides with Diselenides and Selenyl Chlorides

Author(s) -

He Meicui,

Gu Linghui,

Tan Yuqiang,

Wang Yang,

Wang Yuchi,

Zhang Chunran,

Ma Wenbo

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000948

Subject(s) - chemistry , metalation , palladium , aryl , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl

A convenient and effective method of palladium‐catalyzed C−H selenylation of the 2‐aryl acetamides assisted with removable 8‐aminoquinoline with readily available diselenides and selenyl chlorides has been developed. This selenylation reaction is scalable and tolerates a wide range of functional groups, providing a straightforward way of the preparing unsymmetrical diaryl selenides and dibenzoselene‐pinone. Preliminary mechanistic studies indicated that a single‐electron transfer type mechanism and facile C−H metalation are operative.

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