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Palladium‐Catalyzed Distal C−H Selenylation of 2‐Aryl Acetamides with Diselenides and Selenyl Chlorides
Author(s) -
He Meicui,
Gu Linghui,
Tan Yuqiang,
Wang Yang,
Wang Yuchi,
Zhang Chunran,
Ma Wenbo
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000948
Subject(s) - chemistry , metalation , palladium , aryl , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl
A convenient and effective method of palladium‐catalyzed C−H selenylation of the 2‐aryl acetamides assisted with removable 8‐aminoquinoline with readily available diselenides and selenyl chlorides has been developed. This selenylation reaction is scalable and tolerates a wide range of functional groups, providing a straightforward way of the preparing unsymmetrical diaryl selenides and dibenzoselene‐pinone. Preliminary mechanistic studies indicated that a single‐electron transfer type mechanism and facile C−H metalation are operative.