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Enantioselective Formal Arylation of (7‐Aza)isatylidene Malononitriles with α′‐Alkylidene‐2‐cyclohexenones
Author(s) -
He Qing,
Yang ZhenHong,
Yang Jing,
Du Wei,
Chen YingChun
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000900
Subject(s) - chemistry , aromatization , oxindole , enantioselective synthesis , formal synthesis , catalysis , intermolecular force , tandem , combinatorial chemistry , organic chemistry , stereochemistry , molecule , materials science , composite material
An asymmetric intermolecular Rauhut‐Currier reaction of α′‐alkylidene 2‐cyclohexenones and (7‐aza)isatinylidene malononitriles is realized under the double activation catalysis of natural quinine and 2‐mercaptobenzoic acid, finally affording formal 3‐arylated spiro (7‐aza)oxindole derivatives in fair to excellent enantioselectivity after a tandem cyclization/aromatization process (up to 96% ee ).