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Unsymmetrical Disulfides Synthesis via Cs 2 CO 3 ‐Catalyzed Three‐Component Reaction in Water
Author(s) -
Wang Dungai,
Gao Yuanji,
Tong Yunli,
Xiong Mingteng,
Liang Xiao,
Zhu Heping,
Pan Yuanjiang
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000851
Subject(s) - chemistry , catalysis , sulfur , substrate (aquarium) , halide , functional group , combinatorial chemistry , sodium thiosulfate , biomolecule , coupling reaction , component (thermodynamics) , organic chemistry , oceanography , geology , polymer , biochemistry , physics , thermodynamics
An unsymmetrical disulfides synthesis by Cs 2 CO 3 ‐catalyzed three‐component coupling reaction of thioacetate, sodium thiosulfate, and benzyl halide in water is described. The safe, stable, and non‐toxic Na 2 S 2 O 3 was invoked as the sulfur‐source, successfully avoiding the odor generation in the process of S−S bond formation. A wide range of substrate suitability and appropriate functional group tolerance were observed for the transformation. Notably, the approach reported here was compatible with various biomolecules including glucose, coumarin, and quinolinone.