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Asymmetric Fluorination Reactions promoted by Chiral Hydrogen Bonding‐based Organocatalysts
Author(s) -
AuriaLuna Fernando,
Mohammadi Somayeh,
Divar Masoumeh,
Gimeno M. Concepción,
Herrera Raquel P.
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000848
Subject(s) - chemistry , squaramide , thio , organocatalysis , fluorine , hydrogen bond , phosphoric acid , organic chemistry , catalysis , aside , combinatorial chemistry , enantioselective synthesis , computational chemistry , molecule , art , literature
Fluorinated compounds can exhibit interesting biological properties. The importance of these species has made that the chemistry of fluorine has experienced a great development. On this review, the recent advances on asymmetric fluorination reactions promoted by chiral hydrogen bonding‐based organocatalysts are discussed. Hence, examples using phosphoric acid, carboxylic acid, (thio)urea and squaramide derivatives are illustrated. The growth of this field is amazing. We have only considered pivotal works in which direct fluorination takes place using a fluorinating agent, leaving aside the reactions where a fluorine atom is incorporated from the beginning as part of other reactants. Herein, the scarce existing examples on this field of research have been compiled.