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Palladium/Norbornene‐Catalyzed Sequential ortho ‐Acylation and ipso ‐Alkenylation with Carboxylic Acid: Access to Polysubstituted Aryl Ketones
Author(s) -
Yang Shimin,
Feng Yunxia,
Zhao Shen,
Chen Lei,
Li Xinjin,
Zhang Daopeng,
Liu Hui,
Dong Yunhui,
Sun FengGang
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000799
Subject(s) - chemistry , norbornene , aryl , acylation , catalysis , palladium , carboxylic acid , activator (genetics) , organic chemistry , alkyl , medicinal chemistry , copolymer , biochemistry , gene , polymer
Herein a palladium/norbornene‐catalyzed sequential ortho ‐acylation and ispo ‐alkenylation for access to polysubstituted aryl ketones has been developed. By exploiting dicyclohexylcarbodiimide (DCC) as activator, aryl with electron‐donating or electron‐withdrawing functionalities, alkyl, and heteroaryl carboxylic acids were compatible in this transformation, affording the desired products in decent to good yields.