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Cu‐Catalysed Three‐Component Reaction of Aryldiazonium Salts with Fluorinated Diazo Reagents and Nitriles: Access to Difluoro‐ and Trifluoromethylated N 1 ‐Aryl‐1,2,4‐triazoles
Author(s) -
Peng Xing,
Zhang FaGuang,
Ma JunAn
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000776
Subject(s) - chemistry , diazo , reagent , aryl , annulation , combinatorial chemistry , component (thermodynamics) , organic chemistry , catalysis , alkyl , physics , thermodynamics
A copper‐catalysed three‐component reaction of aryldiazonium salts with fluorinated diazo reagents and nitriles is described. This formal [1+2+2] annulation protocol provides rapid access to a diverse array of difluoro‐ and trifluoromethylated N 1 ‐aryl‐1,2,4‐triazoles under simple conditions. The synthetic applicability to divergent drug‐like 1,2,4‐triazoles is also demonstrated.