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Accessing 1,8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine N ‐oxides/Acid‐Mediated Cyclization
Author(s) -
Zhao Lianbo,
Hao Lei,
Fu Yupeng,
Cheng Yan,
Pan Guojun,
Désaubry Laurent,
Yu Peng,
Wang Dong
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000769
Subject(s) - regioselectivity , amination , pyridine , combinatorial chemistry , chemistry , metal , substrate (aquarium) , scope (computer science) , organic chemistry , computer science , catalysis , programming language , oceanography , geology
A concise and practical method for the metal‐free synthesis of 1,8‐naphthyridones is described using a two‐step approach involving regioselective amination of pyridine N ‐oxides and acid‐mediated cyclization. This is the first synthesis of 1,8‐naphthyridones utilizing easily accessible pyridine N ‐oxides as substrates. Compared to previous reports, this method benefits from simple operation, easy access to starting materials, and a wide substrate scope, providing a variety of novel 1,8‐naphthyridones.