Accessing 1,8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine  N ‐oxides/Acid‐Mediated Cyclization | Zendy

Zhao Lianbo | Zendy; Hao Lei | Zendy; Fu Yupeng | Zendy; Cheng Yan | Zendy; Pan Guojun | Zendy; Désaubry Laurent | Zendy; Yu Peng | Zendy; Wang Dong | Zendy

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Accessing 1,8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine N ‐oxides/Acid‐Mediated Cyclization

Author(s) -

Zhao Lianbo,

Hao Lei,

Fu Yupeng,

Cheng Yan,

Pan Guojun,

Désaubry Laurent,

Yu Peng,

Wang Dong

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.202000769

Subject(s) - regioselectivity , amination , pyridine , combinatorial chemistry , chemistry , metal , substrate (aquarium) , scope (computer science) , organic chemistry , computer science , catalysis , programming language , oceanography , geology

A concise and practical method for the metal‐free synthesis of 1,8‐naphthyridones is described using a two‐step approach involving regioselective amination of pyridine N ‐oxides and acid‐mediated cyclization. This is the first synthesis of 1,8‐naphthyridones utilizing easily accessible pyridine N ‐oxides as substrates. Compared to previous reports, this method benefits from simple operation, easy access to starting materials, and a wide substrate scope, providing a variety of novel 1,8‐naphthyridones.

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