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Recent Advancements on Transition‐Metal‐Catalyzed, Chelation‐Induced ortho ‐Hydroxylation of Arenes
Author(s) -
Iqbal Zafar,
Joshi Asha,
Ranjan De Saroj
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.202000762
Subject(s) - chemistry , hydroxylation , regioselectivity , catalysis , transition metal , phenols , chelation , organic chemistry , combinatorial chemistry , enzyme
The phenols are key intermediates as well as desired products in many target oriented syntheses. The conversion of C−H bond to C−O bond is one of the most challenging tasks in organic synthesis. In last few decades, the hydroxylation of aromatic compounds has drawn a considerable attention because of their importance in Pharmaceutical industry, material chemistry, polymers and in agrochemicals. Indeed, transition‐metal‐catalyzed, coordination‐assisted regio‐ and chemoselective ortho ‐hydroxylation of arenes has become very efficient and popular strategy to obtain good yields of phenols with tolerance of a wide range of functional groups. This review is the comprehensive summary of recent advancement on Pd‐, Ru‐, Rh‐, Cu‐ and Ir‐catalyzed, chelation‐controlled regioselective ortho ‐C−H bond hydroxylation of aromatic compounds in the presence of diverse hydroxylating agents. The review has been classified on the sources of hydroxylating agents used in reaction.